Biotin-PEG4-amide-Alkyne

• CAT Number: I015735
• CAS Number: 1006592-45-5
• Molecular Formula: C₂₄H₄₀N₄O₇S
• Molecular Weight: 528.66
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[3-oxo-3-(prop-2-ynylamino)propoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide
• InChI: InChI=1S/C24H40N4O7S/c1-2-8-25-22(30)7-10-32-12-14-34-16-17-35-15-13-33-11-9-26-21(29)6-4-3-5-20-23-19(18-36-20)27-24(31)28-23/h1,19-20,23H,3-18H2,(H,25,30)(H,26,29)(H2,27,28,31)/t19-,20-,23-/m0/s1
• InChIKey: YJLJWRIKUZDUPV-JTAQYXEDSA-N
• SMILES: C#CCNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@H]1[C@@H]2[C@H](CS1)NC(=O)N2

Biotin-PEG4-amide-Alkyne (Cat.No:I015735) is a chemical compound. It is a derivative of biotin, a vitamin essential for various biological processes. Biotin-PEG4-amide-Alkyne contains an alkyne functional group, making it useful in bioconjugation reactions to label biomolecules with azide-containing molecules using click chemistry. The addition of PEG4 (polyethylene glycol 4) enhances solubility and reduces nonspecific binding. Biotin-PEG4-amide-Alkyne is commonly used in research applications for the detection and purification of biotinylated molecules.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562