Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide

• CAT Number: I043860
• CAS Number: 2599839-59-3
• Molecular Formula: C47H67N9O10SSi
• Molecular Weight: 978.24
• Purity: ≥95%
• Synonyms: N-[3-[[1-[3-[2-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-2-methylpropan-2-yl]oxy-diphenylsilyl]oxypropyl]-6-(azidomethyl)pyridine-3-carboxamide
• InChI: InChI=1S/C47H67N9O10SSi/c1-47(2,66-68(38-12-5-3-6-13-38,39-14-7-4-8-15-39)65-23-11-21-50-45(59)36-18-19-37(51-32-36)33-53-56-48)35-52-43(58)20-24-61-26-28-63-30-31-64-29-27-62-25-22-49-42(57)17-10-9-16-41-44-40(34-67-41)54-46(60)55-44/h3-8,12-15,18-19,32,40-41,44H,9-11,16-17,20-31,33-35H2,1-2H3,(H,49,57)(H,50,59)(H,52,58)(H2,54,55,60)/t40-,41-,44-/m0/s1
• InChIKey: SGCWLLPKOCPPEB-UEMJTUMQSA-N
• SMILES: CC(C)(CNC(=O)CCOCCOCCOCCOCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2)O[Si](C3=CC=CC=C3)(C4=CC=CC=C4)OCCCNC(=O)C5=CN=C(C=C5)CN=[N+]=[N-]

Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide is a clickable, acid-cleavable biotin-picolyl azide. Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide is an enrichment handle of cell surface glycoproteins for protein labeling[1].

Reference

[1]. Benjamin Schumann, et al. Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells. Mol Cell. 2020 Jun 4;78(5):824-834.e15.
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