Biotin-PEG6-NHS ester

• CAT Number: I014220
• CAS Number: 2055045-04-8
• Molecular Formula: C29H48N4O12S
• Molecular Weight: 676.78
• Purity: ≥95%
• Synonyms: Biotin-PEG6-NHS ester;2,5-dioxopyrrolidin-1-yl 23-oxo-27-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10,13,16,19-hexaoxa-22-azaheptacosanoate
• Target: PROTAC Linkers
• Solubility: Soluble in DMSO
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C29H48N4O12S/c34-24(4-2-1-3-23-28-22(21-46-23)31-29(38)32-28)30-8-10-40-12-14-42-16-18-44-20-19-43-17-15-41-13-11-39-9-7-27(37)45-33-25(35)5-6-26(33)36/h22-23,28H,1-21H2,(H,30,34)(H2,31,32,38)/t22-,23-,28-/m0/s1
• InChIKey: QWDVPTVNWZPKBQ-LXWOLXCRSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@H]2[C@@H]3[C@H](CS2)NC(=O)N3

Biotin-PEG6-NHS ester（Cat No.:I014220）is a bioconjugation reagent used in molecular biology and biochemistry. It consists of a biotin molecule linked to a six-unit polyethylene glycol (PEG) spacer and an NHS (N-hydroxysuccinimide) ester group. The NHS ester reacts with amine groups on proteins or other biomolecules, allowing for the covalent attachment of biotin to these molecules. The PEG spacer enhances solubility and reduces non-specific binding. This compound is commonly used in applications like protein labeling, affinity purification, and assays involving streptavidin-biotin interactions, as the biotin binds strongly to streptavidin or avidin.