For research use only. Not for therapeutic Use.
Bioymifi (CAT: I005767) is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells. It exhibits the ability to promote cell death without the need for the Smac mimetic in T98G cells. At a concentration of 10 μM, Bioymifi induces the processing of caspase-3 into smaller fragments, and this caspase-mediated cleavage is inhibited by Z-VAD. In T98G cells, caspase-3 is rapidly activated as early as 2 hours after Bioymifi treatment, and its activity is significantly increased after 8 hours of treatment. Furthermore, Bioymifi induces caspase-8-dependent apoptosis.
| Catalog Number | I005767 |
| CAS Number | 1420071-30-2 |
| Synonyms | DR5 Activator;(Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione; |
| Molecular Formula | C22H12BrN3O4S |
| Purity | ≥95% |
| Target | TNF-α |
| Solubility | DMSO: soluble2 mg/mL, clear (warmed) |
| Storage | 2-8°C |
| InChI | InChI=1S/C22H12BrN3O4S/c23-12-2-4-13(5-3-12)26-21(29)18(31-22(26)24)10-14-6-8-17(30-14)11-1-7-15-16(9-11)20(28)25-19(15)27/h1-10,24H,(H,25,27,28)/b18-10-,24-22? |
| InChIKey | ULBOWKXOFOTCMU-NLDKGBHCSA-N |
| SMILES | BrC(C=C1)=CC=C1N2C(S/C(C2=O)=CC3=CC=C(C4=CC=C(C(NC5=O)=O)C5=C4)O3)=N |
| Reference | [1]. Wang G, et al. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat Chem Biol. 2013 Feb;9(2):84-9. |
