BIRH 414

• CAT Number: R042535
• CAS Number: 133627-17-5
• Molecular Formula: C14H14N4O
• Molecular Weight: 254.293
• Purity: ≥95%
• Synonyms: 11-Ethyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2’,3’-e][1,4]diazepin-6-one; BIRH 414 BS; USP Nevirapine Related Compound A
• Storage: 3 years -20C powder
• IUPAC Name: 11-ethyl-4-methyl-5H-dipyrido[2,3-e:2/',3/'-f][1,4]diazepin-6-one
• InChI: InChI=1S/C14H14N4O/c1-3-18-12-10(5-4-7-15-12)14(19)17-11-9(2)6-8-16-13(11)18/h4-8H,3H2,1-2H3,(H,17,19)
• InChIKey: HDVZWQWXAQRFKJ-UHFFFAOYSA-N
• SMILES: CCN1C2=C(C=CC=N2)C(=O)NC3=C(C=CN=C31)C

BIRH 414(CAT: R042535), recognized as an impurity in Nevirapine, stems from 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine, a potent inhibitor of wild-type human immunodeficiency virus type 1. BIRH 414 functions as a derivative of this compound and demonstrates binding affinity towards the HIV-1 reverse transcriptase enzyme. While being an impurity, BIRH 414’s association with Nevirapine points to its presence as a byproduct of the synthesis or degradation process.