For research use only. Not for therapeutic Use.
Bis-aminooxy-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I014227 |
| CAS Number | 93460-33-4 |
| Synonyms | O-[2-(2-aminooxyethoxy)ethyl]hydroxylamine |
| Molecular Formula | C4H12N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C4H12N2O3/c5-8-3-1-7-2-4-9-6/h1-6H2 |
| InChIKey | ZESQVNWRUDEXNZ-UHFFFAOYSA-N |
| SMILES | C(CON)OCCON |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
