For research use only. Not for therapeutic Use.
Bis-aminooxy-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I014228 |
| CAS Number | 98627-71-5 |
| Synonyms | O-[2-[2-(2-aminooxyethoxy)ethoxy]ethyl]hydroxylamine |
| Molecular Formula | C6H16N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C6H16N2O4/c7-11-5-3-9-1-2-10-4-6-12-8/h1-8H2 |
| InChIKey | FDBZGQLBKGNQFT-UHFFFAOYSA-N |
| SMILES | C(COCCON)OCCON |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
