For research use only. Not for therapeutic Use.
Bis-aminooxy-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I014230 |
| CAS Number | 98627-72-6 |
| Synonyms | O-[2-[2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]hydroxylamine |
| Molecular Formula | C10H24N2O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H24N2O6/c11-17-9-7-15-5-3-13-1-2-14-4-6-16-8-10-18-12/h1-12H2 |
| InChIKey | PWNMUXWMRYYPNL-UHFFFAOYSA-N |
| SMILES | C(COCCOCCON)OCCOCCON |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
