For research use only. Not for therapeutic Use.
Bis-PEG1-acid（Cat No.:I014243） is a PEG derivative that possesses two carboxylic acid groups at its terminals. These acid groups can react with primary amine groups, facilitated by activators like EDC or DCC, to form stable amide bonds. This feature makes Bis-PEG1-acid suitable for use in the development of antibody-drug conjugates (ADCs) where it can serve as a linker between the antibody and the drug payload. PEG linkers play a crucial role in enhancing the stability, solubility, and pharmacokinetics of ADCs, thereby improving their therapeutic potential.
| Catalog Number | I014243 |
| CAS Number | 5961-83-1 |
| Synonyms | Bis-PEG1-acid;3,3′-oxydipropionic acid |
| Molecular Formula | C6H10O5 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| Storage | -20°C |
| IUPAC Name | 3-(2-carboxyethoxy)propanoic acid |
| InChI | InChI=1S/C6H10O5/c7-5(8)1-3-11-4-2-6(9)10/h1-4H2,(H,7,8)(H,9,10) |
| InChIKey | FOSIWKADJDNVMJ-UHFFFAOYSA-N |
| SMILES | C(COCCC(=O)O)C(=O)O |
| Reference | </br>1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.</br>2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.</br>3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.</br></br> |
