Bis-PEG1-C-PEG1-CH2COOH

• CAT Number: I018602
• CAS Number: 2358775-67-2
• Molecular Formula: C16H30O8
• Molecular Weight: 350.40
• Purity: ≥95%
• Synonyms: 2-[5-[2-[5-(carboxymethoxy)pentoxy]ethoxy]pentoxy]acetic acid
• InChI: InChI=1S/C16H30O8/c17-15(18)13-23-9-5-1-3-7-21-11-12-22-8-4-2-6-10-24-14-16(19)20/h1-14H2,(H,17,18)(H,19,20)
• InChIKey: OAISFDJULXOPPD-UHFFFAOYSA-N
• SMILES: C(CCOCCOCCCCCOCC(=O)O)CCOCC(=O)O

Bis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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