For research use only. Not for therapeutic Use.
The Bis-PEG1-NHS ester（Cat No.:I014244） is a one-unit PEG-containing linker that is resistant to degradation and is suitable for synthesizing antibody-drug conjugates (ADCs). This linker can be used to connect therapeutic drugs to antibodies, allowing for targeted delivery of the drug to specific cells or tissues. Because of its non-degradable nature, it offers greater stability and longer circulation time in the body, potentially enhancing the efficacy of the ADC. The Bis-PEG1-NHS ester is a valuable tool for the development of novel ADCs for the treatment of various diseases.
| Catalog Number | I014244 |
| CAS Number | 65869-64-9 |
| Synonyms | Bis-PEG1-NHS ester;bis(2,5-dioxopyrrolidin-1-yl) 3,3′-oxydipropionate |
| Molecular Formula | C14H16N2O9 |
| Purity | ≥95% |
| Target | ADC Linker |
| Solubility | Soluble in DMSO |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]propanoate |
| InChI | InChI=1S/C14H16N2O9/c17-9-1-2-10(18)15(9)24-13(21)5-7-23-8-6-14(22)25-16-11(19)3-4-12(16)20/h1-8H2 |
| InChIKey | OWCYSDGIJAVHFQ-UHFFFAOYSA-N |
| SMILES | O=C(CCOCCC(ON1C(CCC1=O)=O)=O)ON(C(CC2)=O)C2=O |
| Reference | </br>1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.</br>2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.</br>3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.</br></br> |
