For research use only. Not for therapeutic Use.
Bis-PEG10-acid（Cat No.:I014233）is a compound composed of two polyethylene glycol (PEG) chains, each containing ten ethylene glycol units (PEG10), attached to a carboxylic acid group. The long PEG chains provide enhanced solubility, stability, and biocompatibility, making the compound useful in a variety of biomedical and pharmaceutical applications, such as drug delivery systems and protein conjugation. The carboxylic acid group allows for further functionalization, enabling the attachment of therapeutic agents, biomolecules, or nanoparticles. Bis-PEG10-acid is commonly employed in the design of targeted therapies, controlled release formulations, and bioconjugates for enhanced therapeutic efficacy.
| Catalog Number | I014233 |
| CAS Number | 2055023-26-0 |
| Synonyms | Bis-PEG10-acid;4,7,10,13,16,19,22,25,28,31-decaoxatetratriacontanedioic acid |
| Molecular Formula | C24H46O14 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| IUPAC Name | 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
| InChI | InChI=1S/C24H46O14/c25-23(26)1-3-29-5-7-31-9-11-33-13-15-35-17-19-37-21-22-38-20-18-36-16-14-34-12-10-32-8-6-30-4-2-24(27)28/h1-22H2,(H,25,26)(H,27,28) |
| InChIKey | PPYUGGOOBJIZHK-UHFFFAOYSA-N |
| SMILES | C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O)C(=O)O |
| Reference | </br>1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.</br>2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.</br>3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.</br></br> |
