For research use only. Not for therapeutic Use.
Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
| Catalog Number | I014245 |
| CAS Number | 19364-66-0 |
| Synonyms | 3-[2-(2-carboxyethoxy)ethoxy]propanoic acid |
| Molecular Formula | C8H14O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C8H14O6/c9-7(10)1-3-13-5-6-14-4-2-8(11)12/h1-6H2,(H,9,10)(H,11,12) |
| InChIKey | BOXWYBCUJGWEOJ-UHFFFAOYSA-N |
| SMILES | C(COCCOCCC(=O)O)C(=O)O |
| Reference | [1]. Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298. |
