For research use only. Not for therapeutic Use.
Bis-PEG2-NHS ester (Cat No.:I014247) is a crosslinking agent used in the chemical synthesis of conjugates. The compound consists of a bis-activated ester of 2-unit polyethylene glycol (PEG), with two N-hydroxysuccinimide (NHS) ester groups at each end. The PEG linker provides water solubility and biocompatibility, while the NHS ester groups react with primary amines on the target molecule, forming stable amide bonds. This enables the crosslinking or conjugation of two different molecules such as proteins, peptides, or drugs. Bis-PEG2-NHS ester is commonly used in the production of protein conjugates, including antibody-drug conjugates (ADCs).
| Catalog Number | I014247 |
| CAS Number | 65869-63-8 |
| Synonyms | Bis-PEG2-NHS ester;bis(2,5-dioxopyrrolidin-1-yl) 3,3′-(ethane-1,2-diylbis(oxy))dipropionate |
| Molecular Formula | C16H20N2O10 |
| Purity | ≥95% |
| Target | ADC Linker |
| Solubility | Soluble in DMSO |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]propanoate |
| InChI | InChI=1S/C16H20N2O10/c19-11-1-2-12(20)17(11)27-15(23)5-7-25-9-10-26-8-6-16(24)28-18-13(21)3-4-14(18)22/h1-10H2 |
| InChIKey | SORMJGWNAXHOFC-UHFFFAOYSA-N |
| SMILES | O=C(CCOCCOCCC(ON1C(CCC1=O)=O)=O)ON(C(CC2)=O)C2=O |
| Reference | </br>1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.</br>2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.</br>3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.</br></br> |
