Bis-PEG25-NHS ester

• CAT Number: I016927
• CAS Number: 2221948-96-3
• Molecular Formula: C62H112N2O33
• Molecular Weight: 1413.55
• Purity: ≥95%

Bis-PEG25-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG25-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Reference

[1]. John L. Magnani, et al. Highly potent multimeric e-selectin antagonists. WO2018068010A1