For research use only. Not for therapeutic Use.
Bis-PEG4-acid is a polyethylene glycol (PEG) derivative with two terminal carboxylic acid groups. These acid groups can be reacted with primary amine groups, utilizing activators such as EDC or DCC, to form stable amide bonds. PEG linkers, including Bis-PEG4-acid, are valuable tools in the development of antibody-drug conjugates (ADCs). By conjugating the PEG linker to an antibody, the linker enables the attachment of therapeutic drugs, facilitating targeted drug delivery and enhancing the efficacy of ADCs in cancer treatment.
| Catalog Number | I014250 |
| CAS Number | 31127-85-2 |
| Synonyms | Bis-PEG4-acid;4,7,10,13-tetraoxahexadecanedioic acid |
| Molecular Formula | C12H22O8 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| Storage | Room Temperature |
| IUPAC Name | 3-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]propanoic acid |
| InChI | InChI=1S/C12H22O8/c13-11(14)1-3-17-5-7-19-9-10-20-8-6-18-4-2-12(15)16/h1-10H2,(H,13,14)(H,15,16) |
| InChIKey | LGEVPLDBBPWJIC-UHFFFAOYSA-N |
| SMILES | C(COCCOCCOCCOCCC(=O)O)C(=O)O |
| Reference | </br>1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.</br>2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.</br>3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.</br></br> |
