For research use only. Not for therapeutic Use.
Bis-PEG4-NHS ester(CAT: I014251) is a polyethylene glycol (PEG)-based compound that contains two PEG chains linked by an NHS ester group. The NHS ester moiety allows for selective coupling to primary amines, forming stable amide bonds. This compound is commonly used in bioconjugation and drug delivery applications, where it is employed as a crosslinker or spacer to link molecules or modify surfaces. Its PEG backbone provides water solubility and biocompatibility, making it suitable for various biomedical applications.
| Catalog Number | I014251 |
| CAS Number | 1314378-11-4 |
| Synonyms | Bis-PEG4-NHS ester;bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13-tetraoxahexadecanedioate |
| Molecular Formula | C20H28N2O12 |
| Purity | ≥95% |
| Target | ADC Linker |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C20H28N2O12/c23-15-1-2-16(24)21(15)33-19(27)5-7-29-9-11-31-13-14-32-12-10-30-8-6-20(28)34-22-17(25)3-4-18(22)26/h1-14H2 |
| InChIKey | BQLKLYYHZOLCLV-UHFFFAOYSA-N |
| SMILES | O=C(CCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)ON(C(CC2)=O)C2=O |
| Reference | </br>1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.</br>2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.</br>3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.</br></br> |
