For research use only. Not for therapeutic Use.
Bis-PEG5-NHS ester（Cat No.:I014252）, is a chemical compound used as a crosslinking reagent in bioconjugation and drug delivery applications. It is a polyethylene glycol (PEG) derivative that contains multiple N-hydroxysuccinimide (NHS) ester functional groups. These NHS ester groups react selectively with primary amines, allowing for the covalent conjugation of biomolecules such as proteins and peptides. Bis-PEG5-NHS ester enables the creation of stable and bioactive conjugates, making it valuable in various biomedical and research fields, including drug development, diagnostics, and targeted therapy.
| Catalog Number | I014252 |
| CAS Number | 756526-03-1 |
| Synonyms | Bis-PEG5-NHS ester;bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16-pentaoxanonadecanedioate |
| Molecular Formula | C22H32N2O13 |
| Purity | ≥95% |
| Target | PROTAC |
| Solubility | Soluble in DMSO |
| Storage | -20°C |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| InChI | InChI=1S/C22H32N2O13/c25-17-1-2-18(26)23(17)36-21(29)5-7-31-9-11-33-13-15-35-16-14-34-12-10-32-8-6-22(30)37-24-19(27)3-4-20(24)28/h1-16H2 |
| InChIKey | FTYUGLBWKRXQBD-UHFFFAOYSA-N |
| SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O |
| Reference | </br>1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.</br>2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.</br>3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.</br></br> |
