For research use only. Not for therapeutic Use.
Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
| Catalog Number | I014253 |
| CAS Number | 119189-70-7 |
| Synonyms | 3-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
| Molecular Formula | C16H30O10 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H30O10/c17-15(18)1-3-21-5-7-23-9-11-25-13-14-26-12-10-24-8-6-22-4-2-16(19)20/h1-14H2,(H,17,18)(H,19,20) |
| InChIKey | YFBGEYNLLRKUTP-UHFFFAOYSA-N |
| SMILES | C(COCCOCCOCCOCCOCCOCCC(=O)O)C(=O)O |
| Reference | [1]. Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292. |
