For research use only. Not for therapeutic Use.
Bis-PEG6-NHS ester（Cat No.:I014254） is a PEG-class PROTAC junction bridge commonly used in the synthesis of PROTAC molecules. It serves as a versatile linker that can connect two different small molecules to form a PROTAC, facilitating targeted protein degradation. Additionally, Bis-PEG6-NHS ester functions as a cleavable ADC linker, enabling the conjugation of drugs to antibodies for the development of antibody-drug conjugates (ADCs). This compound plays a crucial role in the creation of novel therapeutics by enabling precise molecular targeting and controlled drug release.
| Catalog Number | I014254 |
| CAS Number | 1526718-98-8 |
| Synonyms | Bis-PEG6-NHS ester;bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate |
| Molecular Formula | C24H36N2O14 |
| Purity | ≥95% |
| Target | PROTAC |
| Solubility | Soluble in DMSO |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| InChI | InChI=1S/C24H36N2O14/c27-19-1-2-20(28)25(19)39-23(31)5-7-33-9-11-35-13-15-37-17-18-38-16-14-36-12-10-34-8-6-24(32)40-26-21(29)3-4-22(26)30/h1-18H2 |
| InChIKey | FDLGRFGWAMAWTE-UHFFFAOYSA-N |
| SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O |
| Reference | </br>1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.</br>2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.</br>3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.</br></br> |
