For research use only. Not for therapeutic Use.
Bis-PEG7-NHS ester (Cat No.:I014256) is a chemical compound used in bioconjugation and drug delivery applications. It is a derivative of polyethylene glycol (PEG) that contains two PEG chains and an N-hydroxysuccinimide (NHS) ester functional group. Bis-PEG7-NHS ester facilitates the conjugation of PEG molecules to biomolecules, such as proteins or peptides, via amine groups. This conjugation enhances the stability, solubility, and pharmacokinetics of the biomolecules, making it valuable in the development of targeted therapies and biomedical research.
Catalog Number | I014256 |
CAS Number | 1334170-02-3 |
Synonyms | Bis-PEG7-NHS ester;bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19,22-heptaoxapentacosanedioate |
Molecular Formula | C26H40N2O15 |
Purity | ≥95% |
Target | PROTAC |
Solubility | Soluble in DMSO |
IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
InChI | InChI=1S/C26H40N2O15/c29-21-1-2-22(30)27(21)42-25(33)5-7-35-9-11-37-13-15-39-17-19-41-20-18-40-16-14-38-12-10-36-8-6-26(34)43-28-23(31)3-4-24(28)32/h1-20H2 |
InChIKey | QWDCSPQIVZTPRD-UHFFFAOYSA-N |
SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O |
Reference | </br>1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.</br>2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.</br>3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.</br></br> |