Bis-PEG8-acid

• CAT Number: I014257
• CAS Number: 1246189-43-4
• Molecular Formula: C20H38O12
• Molecular Weight: 470.51
• Purity: ≥95%
• Synonyms: Bis-PEG8-acid;4,7,10,13,16,19,22,25-octaoxaoctacosanedioic acid
• Target: Antibody-drug Conjugate/ADC Related
• Solubility: Soluble in DMSO
• Storage: 2-8°C
• IUPAC Name: 3-[2-[2-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C20H38O12/c21-19(22)1-3-25-5-7-27-9-11-29-13-15-31-17-18-32-16-14-30-12-10-28-8-6-26-4-2-20(23)24/h1-18H2,(H,21,22)(H,23,24)
• InChIKey: IRTAMFHIULAGCS-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCCOCCOCCOCCOCCC(=O)O)C(=O)O

Bis-PEG8-acid（Cat No.:I014257） is a linker molecule that falls under the PEG (polyethylene glycol) class and is commonly used in the synthesis of PROTAC (proteolysis-targeting chimera) molecules. It serves as a cleavable linker for the construction of antibody-drug conjugates (ADCs). Bis-PEG8-acid enables the attachment of drugs to antibodies, allowing for targeted drug delivery. With its ability to be cleaved, Bis-PEG8-acid facilitates the release of the drug payload at the desired site, enhancing the therapeutic efficacy of the ADCs.

Reference

1: Bonache MA, Alaimo A, Malo C, Millet O, Villarroel A, González-Muñiz R. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding. Org Biomol Chem. 2014 Nov 28;12(44):8877-87. doi: 10.1039/c4ob01338g. PubMed PMID: 25264745.2: Aroua S, Schweizer WB, Yamakoshi Y. C60 pyrrolidine bis-carboxylic acid derivative as a versatile precursor for biocompatible fullerenes. Org Lett. 2014 Mar 21;16(6):1688-91. doi: 10.1021/ol500363r. Epub 2014 Mar 7. PubMed PMID: 24606113.3: Kakkar D, Tiwari AK, Chuttani K, Khanna A, Datta A, Singh H, Mishra AK. Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chem Biol Drug Des. 2012 Aug;80(2):245-53. doi: 10.1111/j.1747-0285.2012.01394.x. Epub 2012 May 30. PubMed PMID: 22515497.