For research use only. Not for therapeutic Use.
Bis-propargyl-PEG2（Cat No.:I014263）is a compound consisting of a polyethylene glycol (PEG) backbone with two propargyl groups attached at either end. The PEG segment enhances the compound’s solubility and biocompatibility, while the propargyl groups serve as reactive sites for click chemistry or other conjugation reactions. This makes bis-propargyl-PEG2 useful in drug delivery systems, biomedical applications, and the synthesis of bioconjugates. Its structure allows for targeted drug delivery, facilitating the attachment of therapeutic agents, proteins, or imaging molecules. Ongoing research explores its potential in creating advanced nanomedicines and medical devices.
| Catalog Number | I014263 |
| CAS Number | 40842-04-4 |
| Synonyms | Bis-propargyl-PEG2;1,2-bis(prop-2-yn-1-yloxy)ethane |
| Molecular Formula | C8H10O2 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| IUPAC Name | 3-(2-prop-2-ynoxyethoxy)prop-1-yne |
| InChI | InChI=1S/C8H10O2/c1-3-5-9-7-8-10-6-4-2/h1-2H,5-8H2 |
| InChIKey | RNHWCSPBGKGOLM-UHFFFAOYSA-N |
| SMILES | C#CCOCCOCC#C |
| Reference | </br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550. </br>2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. PubMed PMID: 27021417.</br>3: Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). pii: E1190. doi: 10.3390/molecules22071190. PubMed PMID: 28714870; PubMed Central PMCID: PMC5776016.</br>4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. PubMed PMID: 7578129. </br> </br> |
