Bis-propargyl-PEG3

• CAT Number: I016887
• CAS Number: 126422-58-0
• Molecular Formula: C12H18O4
• Molecular Weight: 226.27
• Purity: ≥95%
• Synonyms: 3-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]prop-1-yne
• InChI: InChI=1S/C12H18O4/c1-3-5-13-7-9-15-11-12-16-10-8-14-6-4-2/h1-2H,5-12H2
• InChIKey: PHRQSGRBGBTBAD-UHFFFAOYSA-N
• SMILES: C#CCOCCOCCOCCOCC#C

Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity[1] [2]. Bis-propargyl-PEG3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity against three strains of Plasmodium falciparum [2].

Reference

[1]. Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.

[2]. Rice DR, et al. Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes. Bioorg Med Chem. 2017 May 15;25(10):2754-2760.
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