For research use only. Not for therapeutic Use.
Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers[1][2]. Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Bis-propargyl-PEG4 can be used in the synthesis of demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis[2].
| Catalog Number | I014264 |
| CAS Number | 159428-42-9 |
| Synonyms | 3-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]prop-1-yne |
| Molecular Formula | C14H22O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H22O5/c1-3-5-15-7-9-17-11-13-19-14-12-18-10-8-16-6-4-2/h1-2H,5-14H2 |
| InChIKey | FCPHAZIYRMYSTF-UHFFFAOYSA-N |
| SMILES | C#CCOCCOCCOCCOCCOCC#C |
| Reference | [1]. Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2. [2]. Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533. |
