Bis-propargyl-PEG7

• CAT Number: I014265
• CAS Number: 1351373-46-0
• Molecular Formula: C20H34O8
• Molecular Weight: 402.48
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-yne
• InChI: InChI=1S/C20H34O8/c1-3-5-21-7-9-23-11-13-25-15-17-27-19-20-28-18-16-26-14-12-24-10-8-22-6-4-2/h1-2H,5-20H2
• InChIKey: VVUXHSSWSXTRPE-UHFFFAOYSA-N
• SMILES: C#CCOCCOCCOCCOCCOCCOCCOCCOCC#C

Bis-propargyl-PEG7 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG7 can be used to synthesize the polymer linked multimers of guanosine-3′, 5′-cyclic monophosphates[1]. Bis-propargyl-PEG7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Bis-propargyl-PEG6 can be used to synthesize the polymer linked multimers of guanosine-3′, 5′-cyclic monophosphates which can be used as reagents for signal transduction research and as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and as ligands for affinity chromatography, for antibody production or for diagnostic applications e.g. on chip surfaces[1].

Reference

[1]. Hans-Gottfried Genieser, et al. New polymer linked multimers of guanosine-3′, 5′-cyclic monophosphates. WO2018041942A1.