Bisantrene dihydrochloride

• CAT Number: I042685
• CAS Number: 71439-68-4
• Molecular Formula: C22H24Cl2N8
• Molecular Weight: 471.39
• Purity: ≥95%
• Synonyms: N-[(E)-[10-[(E)-(4,5-dihydro-1H-imidazol-2-ylhydrazinylidene)methyl]anthracen-9-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;dihydrochloride
• InChI: InChI=1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H/b27-13+,28-14+
• InChIKey: KINULKKPVJYRON-PVNXHVEDSA-N
• SMILES: C1NC(=NC1)N/N=C/C2=C3C(=C(C4=CC=CC=C24)/C=N/NC5=NCCN5)C=CC=C3.Cl.Cl

Bisantrene dihydrochloride（Cat No.:I042685）is a synthetic anthraquinone derivative and a potent anticancer agent. It works by intercalating into DNA, inhibiting topoisomerase II activity, and disrupting the transcription and replication processes in rapidly dividing cancer cells. This leads to DNA damage, cell cycle arrest, and eventual apoptosis. Bisantrene dihydrochloride has shown efficacy against various cancers, including leukemia and solid tumors, and is being studied as a potential treatment for drug-resistant cancers. Ongoing research is focused on evaluating its safety, efficacy, and therapeutic potential, both as a monotherapy and in combination with other cancer treatments.