Bisdemethoxycurcumin

• CAT Number: R022612
• CAS Number: 24939-16-0
• Molecular Formula: C19H16O4
• Molecular Weight: 308.333
• Purity: ≥95%
• Synonyms: 1,7-Bis(p-hydroxyphenyl)-1,6-heptadiene-3,5-dione; Bis(4-hydroxycinnamoyl)methane; Bisdemethoxycucurmin; p,p’-Dihydroxydicinnamoylmethane
• Target: Disease Research Fields
• Storage: -20°C
• IUPAC Name: (1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
• InChI: InChI=1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
• InChIKey: PREBVFJICNPEKM-YDWXAUTNSA-N
• SMILES: C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-<wbr></wbr>dihydroxy vitamin D3 to stimulate amyloid-<wbr></wbr>β clearance by macrophages (optimal stimulation at 100 nM BDMC). More stable than curcumin in physiological media, BDMC suppresses proliferation in cancer cells. It down-<wbr></wbr>regulates the transcriptional coactivator p300, suppressing the Wnt/β-<wbr></wbr>catenin pathway, and inhibits LPS induction of iNOS expression.