Bisindolylmaleimide I

• CAT Number: I001259
• CAS Number: 133052-90-1
• Molecular Formula: C₂₅H₂₄N₄O₂
• Molecular Weight: 412.49
• Purity: ≥95%
• Synonyms: 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
• Target: TGF-beta/Smad
• Solubility: DMSO
• Storage: Store at RT
• InChI: CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
• InChIKey: QMGUOJYZJKLOLH-UHFFFAOYSA-N
• SMILES: 1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)

Bisindolylmaleimide I (Cat No.: I001259) is a selective inhibitor of protein kinase C (PKC), a family of enzymes involved in various cellular processes such as cell growth, differentiation, and apoptosis. It has been widely used in research to study PKC’s role in signaling pathways. Bisindolylmaleimide I has shown potential in cancer research, as PKC is often dysregulated in tumors. Additionally, it has been explored for its anti-inflammatory, neuroprotective, and cardioprotective effects in preclinical models of diseases like neurodegeneration and heart failure.