For research use only. Not for therapeutic Use.
Bisindolylmaleimide II is a general inhibitor of all PKC subtypes[1].
| Catalog Number | I010898 |
| CAS Number | 137592-45-1 |
| Synonyms | 3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione |
| Molecular Formula | C27H26N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33) |
| InChIKey | LBFDERUQORUFIN-UHFFFAOYSA-N |
| SMILES | CN1CCCC1CCN2C=C(C3=CC=CC=C32)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65 |
| Reference | [1]. Gassel M, et al. The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A. J Biol Chem. 2004 May 28;279(22):23679-90. |
