BIX 02189

• CAT Number: R016501
• CAS Number: 1094614-85-3
• Molecular Formula: C27H28N4O2
• Molecular Weight: 440.54
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N(C)C)O

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

Reference

[1] Tatake RJ, et al. Biochem Biophys Res Commun, 2008, 377(1), 120-125.
[2] Lim JH, et al. Anat Cell Biol, 2011, 44(4), 265-273.
[3] Kimura TE, et al. Circ Res, 2010, 106(5), 961-970.