BKI-1369

• CAT Number: I018740
• CAS Number: 1951431-22-3
• Molecular Formula: C₂₃H₂₇N₇O
• Molecular Weight: 417.51
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 3-(2-ethoxyquinolin-6-yl)-1-[(1-methylpiperidin-4-yl)methyl]pyrazolo[3,4-d]pyrimidin-4-amine
• InChI: InChI=1S/C23H27N7O/c1-3-31-19-7-5-16-12-17(4-6-18(16)27-19)21-20-22(24)25-14-26-23(20)30(28-21)13-15-8-10-29(2)11-9-15/h4-7,12,14-15H,3,8-11,13H2,1-2H3,(H2,24,25,26)
• InChIKey: AWJAAKKEYXUCFY-UHFFFAOYSA-N
• SMILES: CCOC1=NC2=C(C=C1)C=C(C=C2)C3=NN(C4=NC=NC(=C34)N)CC5CCN(CC5)C

BKI-1369（Cat No.:I018740）, is a potent and selective inhibitor of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) with an IC50 value of 0.038 µM. It has been shown to inhibit the growth of Toxoplasma gondii in vitro and in vivo and may have potential as a treatment for toxoplasmosis. BKI-1369 has also been reported to inhibit the growth of other apicomplexan parasites, including Plasmodium falciparum and Cryptosporidium parvum, suggesting that it may have broader applications as a broad-spectrum anti-parasitic drug.

Reference

[1]. Lee S, et al. Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis. Antimicrob Agents Chemother. 2018 Jun 26;62(7).