BL-918

• CAT Number: I017146
• CAS Number: 2101517-69-3
• Molecular Formula: C₂₃H₁₅F₈N₃OS
• Molecular Weight: 533.44
• Purity: ≥95%
• Target: ULK
• Storage: Store at -20°C
• IUPAC Name: (2R)-2-[[3,5-bis(trifluoromethyl)phenyl]carbamothioylamino]-N-(2,4-difluorophenyl)-2-phenylacetamide
• InChI: InChI=1S/C23H15F8N3OS/c24-15-6-7-18(17(25)11-15)33-20(35)19(12-4-2-1-3-5-12)34-21(36)32-16-9-13(22(26,27)28)8-14(10-16)23(29,30)31/h1-11,19H,(H,33,35)(H2,32,34,36)/t19-/m1/s1
• InChIKey: BDBWQANRZRCMMD-LJQANCHMSA-N
• SMILES: C1=CC=C(C=C1)C(C(=O)NC2=C(C=C(C=C2)F)F)NC(=S)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F

BL-918（Cat No.:I017146） is a small molecule activator of the serine/threonine kinase ULK1, which plays a critical role in the initiation of autophagy. It has potent and selective activity with an EC50 value of 24.14nM and a Kd value of 0.719μM. BL-918 can induce cytoprotective autophagy, making it a potential therapeutic agent for the treatment of Parkinson’s disease. It is orally active, and its ability to cross the blood-brain barrier makes it an attractive candidate for further development.

Reference

[1]. Ouyang L, et al. Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson’s Disease Treatment. J Med Chem. 2018 Apr 12;61(7):2776-2792.