For research use only. Not for therapeutic Use.
(+)-Blebbistatin is the inactive enantiomer of (±)-Blebbistatin (Axon 2718) with an IC50 value of >100 μM for ATPase activity; Negative control for non-muscle myosin II studies. The active enantiomer (-)-Blebbistatin is available as Axon 3074.
KEYWORDS: (+)-Blebbistatin | supplier | Myosin II negative control | CAS [1177356-70-5] | ATP | ATPase (myosin) | Inhibitor | Enzymes
| Catalog Number | R002957 |
| CAS Number | 1177356-70-5 |
| Molecular Formula | C18H16N2O2 |
| Purity | ≥95% |
| IUPAC Name | (3aR)-3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one |
| InChI | InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m0/s1 |
| SMILES | CC1=CC2=C(C=C1)N=C3[C@@](C2=O)(CCN3C4=CC=CC=C4)O |
| Reference | C Lucas-Lopez et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (-)-Blebbistatin. European Journal of Organic Chemistry (2005), (9), 1736-1740. S Verhasselt et al. Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties. Org Biomol Chem. 2017;15(9):2104–2118. |
