For research use only. Not for therapeutic Use.
BLK Degrader 1(CAT: I040988) is a novel PROTAC (Proteolysis Targeting Chimera) designed to selectively degrade B lymphoid tyrosine kinase (BLK), a key regulator in B-cell signaling and immune response. By leveraging the ubiquitin-proteasome system (UPS), this degrader promotes targeted BLK proteolysis, making it a valuable tool for studying B-cell malignancies, autoimmune disorders, and inflammatory diseases. BLK Degrader 1 is optimized for biochemical, cellular, and preclinical studies, providing insights into protein degradation-based therapeutic strategies. For research use only; not for human or clinical applications.
| Catalog Number | I040988 |
| Synonyms | N-[2-(3-aminoanilino)pyrimidin-5-yl]-2-methyl-5-[[4-[3-(trifluoromethyl)phenyl]benzoyl]amino]benzamide |
| Molecular Formula | C32H25F3N6O2 |
| Purity | ≥95% |
| IUPAC Name | N-[2-(3-aminoanilino)pyrimidin-5-yl]-2-methyl-5-[[4-[3-(trifluoromethyl)phenyl]benzoyl]amino]benzamide |
| InChI | InChI=1S/C32H25F3N6O2/c1-19-8-13-26(39-29(42)21-11-9-20(10-12-21)22-4-2-5-23(14-22)32(33,34)35)16-28(19)30(43)40-27-17-37-31(38-18-27)41-25-7-3-6-24(36)15-25/h2-18H,36H2,1H3,(H,39,42)(H,40,43)(H,37,38,41) |
| InChIKey | MGJRUWHJBSOWPN-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)C3=CC(=CC=C3)C(F)(F)F)C(=O)NC4=CN=C(N=C4)NC5=CC=CC(=C5)N |
