BLM-IN-1

• CAT Number: I019395
• CAS Number: 2056014-40-3
• Molecular Formula: C₂₈H₃₅FN₄O
• Molecular Weight: 462.6
• Purity: ≥95%
• Target: Apoptosis
• Storage: Store at -20°C
• IUPAC Name: (3E)-6-[3-(diethylamino)propylamino]-7-fluoro-3-[(4-propan-2-ylphenyl)methylidene]-1,2-dihydropyrrolo[2,1-b]quinazolin-9-one
• InChI: InChI=1S/C28H35FN4O/c1-5-32(6-2)14-7-13-30-26-18-25-23(17-24(26)29)28(34)33-15-12-22(27(33)31-25)16-20-8-10-21(11-9-20)19(3)4/h8-11,16-19,30H,5-7,12-15H2,1-4H3/b22-16+
• InChIKey: GZSNGNPLURZQGM-CJLVFECKSA-N
• SMILES: CCN(CC)CCCNC1=C(C=C2C(=C1)N=C3C(=CC4=CC=C(C=C4)C(C)C)CCN3C2=O)F

BLM-IN-1（Cat No.:I019395）is a small molecule inhibitor that targets the Bloom syndrome protein (BLM), a DNA helicase involved in DNA repair and genomic stability. By inhibiting BLM, BLM-IN-1 can prevent the growth and proliferation of cancer cells that depend on BLM for survival. Preclinical studies have shown that BLM-IN-1 is effective against a variety of cancer types, making it a promising candidate for further development as an anticancer therapy.

Reference

[1]. Yin QK, et al. Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J Med Chem. 2019 Mar 28;62(6):3147-3162.