BLU-222

• CAT Number: I040011
• CAS Number: 2888704-84-3
• Molecular Formula: C15H17F2N7O2
• Molecular Weight: 365.34
• Purity: ≥95%
• Synonyms: N-[3-(difluoromethoxy)-1H-pyrazol-5-yl]-1-(oxan-4-ylmethyl)pyrazolo[3,4-b]pyrazin-6-amine
• InChI: InChI=1S/C15H17F2N7O2/c16-15(17)26-13-5-11(22-23-13)20-12-7-18-10-6-19-24(14(10)21-12)8-9-1-3-25-4-2-9/h5-7,9,15H,1-4,8H2,(H2,20,21,22,23)
• InChIKey: IFJSYTKOMJJYNP-UHFFFAOYSA-N
• SMILES: C1COCCC1CN2C3=NC(=CN=C3C=N2)NC4=CC(=NN4)OC(F)F

BLU-222 (Cat No.: I040011) is a selective and potent CDK2 inhibitor designed for cancer research. Cyclin-dependent kinase 2 (CDK2) plays a crucial role in cell cycle progression, particularly in tumor cells with dysregulated cell cycles. By inhibiting CDK2, BLU-222 may help suppress tumor growth, making it a promising candidate for studying cancers driven by CDK2 overactivity, including breast and ovarian cancers. This inhibitor offers researchers a valuable tool to explore targeted therapies and combination strategies in oncology drug discovery.

Reference

[1]. Talbot T, et al. Amplified therapeutic targets in high-grade serous ovarian carcinoma – a review of the literature with quantitative appraisal. Cancer Gene Ther. 2023 Jul;30(7):955-963.
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