For research use only. Not for therapeutic Use.
BLU0588(CAT: I040908) is an orally active, potent, and selective inhibitor of PRKACA (protein kinase cAMP-activated catalytic subunit alpha), with an IC50 value of 1 nM and a dissociation constant (Kd) of 4 nM. PRKACA is a key enzyme involved in various cellular processes, including signal transduction, metabolism, and cell proliferation. Aberrant activation of PRKACA is implicated in several cancers, including fibrolamellar carcinoma (FLC), a rare and aggressive liver cancer. By selectively inhibiting PRKACA, BLU0588 holds potential for research focused on FLC and may serve as a therapeutic candidate for targeted treatment strategies in this cancer type.
| CAS Number | 2810747-78-3 |
| Synonyms | N-[(1R,2R)-2-pyrrolidin-1-yl-2,3-dihydro-1H-inden-1-yl]-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyridine-3-carboxamide |
| Molecular Formula | C26H25N5O |
| Purity | ≥95% |
| IUPAC Name | N-[(1R,2R)-2-pyrrolidin-1-yl-2,3-dihydro-1H-inden-1-yl]-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyridine-3-carboxamide |
| InChI | InChI=1S/C26H25N5O/c32-26(18-7-8-22(29-16-18)20-9-11-27-25-21(20)10-12-28-25)30-24-19-6-2-1-5-17(19)15-23(24)31-13-3-4-14-31/h1-2,5-12,16,23-24H,3-4,13-15H2,(H,27,28)(H,30,32)/t23-,24-/m1/s1 |
| InChIKey | YXSWSKFLTNJZEO-DNQXCXABSA-N |
| SMILES | C1CCN(C1)C2CC3=CC=CC=C3C2NC(=O)C4=CN=C(C=C4)C5=C6C=CNC6=NC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
