For research use only. Not for therapeutic Use.
BM635（Cat No.:I020343）is a potent inhibitor of MmpL3, an essential transporter in Mycobacterium tuberculosis responsible for cell wall biosynthesis. By targeting MmpL3, BM635 disrupts the transport of mycolic acids, leading to bacterial cell death. It has demonstrated significant anti-mycobacterial activity, with a minimum inhibitory concentration (MIC) of 0.12 μM against M. tuberculosis H37Rv. In vivo studies indicate that BM635 exhibits potent anti-tubercular effects, with an ED99 of 49 mg/kg in a murine model. Its efficacy against drug-resistant strains positions BM635 as a promising candidate in tuberculosis research and drug development.
| Catalog Number | I020343 |
| CAS Number | 1493762-74-5 |
| Molecular Formula | C₂₅H₂₉FN₂O |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 4-[[1-(4-fluorophenyl)-2-methyl-5-(4-propan-2-ylphenyl)pyrrol-3-yl]methyl]morpholine |
| InChI | InChI=1S/C25H29FN2O/c1-18(2)20-4-6-21(7-5-20)25-16-22(17-27-12-14-29-15-13-27)19(3)28(25)24-10-8-23(26)9-11-24/h4-11,16,18H,12-15,17H2,1-3H3 |
| InChIKey | NEEGNYKRJDHJNX-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(N1C2=CC=C(C=C2)F)C3=CC=C(C=C3)C(C)C)CN4CCOCC4 |
| Reference | [1]. Poce G, et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2):e56980.<br>[2]. Poce G, et al. Pharmaceutical salt of BM635 with improved bioavailability. Eur J Pharm Sci. 2017 Mar 1;99:17-23. |
