BMH-23

• CAT Number: I012772
• CAS Number: 510721-85-4
• Molecular Formula: C15H15N3
• Molecular Weight: 237.31
• Purity: ≥95%
• Synonyms: 5-Amino-2,4,9-Trimethylbenzo[b][1,8]naphthyridine
• Target: DNA/RNA Synthesis
• IUPAC Name: 2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine
• InChI: InChI=1S/C15H15N3/c1-8-5-4-6-11-13(16)12-9(2)7-10(3)17-15(12)18-14(8)11/h4-7H,1-3H3,(H2,16,17,18)
• InChIKey: WRUVTYDQVPMYDZ-UHFFFAOYSA-N
• SMILES: CC1=C2C(=CC=C1)C(=C3C(=CC(=NC3=N2)C)C)N

BMH-23(CAT: I012772) is a potent inhibitor of RNA polymerase I (Pol I) transcription, selectively targeting the ribosomal RNA (rRNA) synthesis pathway. By disrupting nucleolar function and inducing nucleolar stress, it effectively halts cancer cell proliferation, leading to apoptosis. Its mechanism is particularly relevant in oncology research, as it exploits the dependency of cancer cells on elevated rRNA production. BMH-23 is a valuable compound for studying nucleolar biology, cancer cell metabolism, and the development of novel anticancer strategies targeting Pol I transcription.