For research use only. Not for therapeutic Use.
BMH-7（Cat No.:I023494）is a small molecule compound that functions as an inhibitor of the protein kinase CK2 (casein kinase 2). CK2 is a serine/threonine kinase involved in regulating various cellular processes, including cell growth, survival, and DNA repair. Dysregulation of CK2 activity has been implicated in various cancers and inflammatory diseases. BMH-7 selectively targets CK2, suppressing its activity and thereby potentially inhibiting tumor cell growth and promoting apoptosis. It is being explored in preclinical studies as a potential therapeutic agent for cancer and other CK2-related pathologies, with a focus on its ability to modulate cellular signaling.
| Catalog Number | I023494 |
| CAS Number | 379247-14-0 |
| Synonyms | BMH-7; BMH7; BMH 7 |
| Molecular Formula | C20H21N5O |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 5-[3-(dimethylamino)propylamino]quinazolino[2,3-a]phthalazin-8-one |
| InChI | InChI=1S/C20H21N5O/c1-24(2)13-7-12-21-18-14-8-3-4-9-15(14)19-22-17-11-6-5-10-16(17)20(26)25(19)23-18/h3-6,8-11H,7,12-13H2,1-2H3,(H,21,23) |
| InChIKey | VYNPQVGFXYNKOX-UHFFFAOYSA-N |
| SMILES | CN(C)CCCNC1=NN2C(=NC3=CC=CC=C3C2=O)C4=CC=CC=C41 |
| Reference | 1: Zhang GH, Yuan JM, Qian G, Gu CX, Wei K, Mo DL, Qin JK, Peng Y, Zhou ZP, Pan CX, Su GF. Phthalazino[1,2-b]quinazolinones as p53 Activators: Cell Cycle Arrest, Apoptotic Response and Bak-Bcl-xl Complex Reorganization in Bladder Cancer Cells. J Med Chem. 2017 Aug 15. doi: 10.1021/acs.jmedchem.6b01769. [Epub ahead of print] PubMed PMID: 28745887. |
