For research use only. Not for therapeutic Use.
BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC<sub>150</sub> value (effective concentration able to increase the enzyme by 150%) of 1 µM. It less potently activates SIRT2 and SIRT3 (EC<sub>150</sub>s = 25 and 50 µM, respectively). BML-278 induces hypoacetylation on α-tubulin in U937 cells that are pretreated with SAHA (Item No. <span class=/itemid/>10009929</span>), a histone deacetylase inhibitor. It arrests cell cycling at the G<sub>1</sub>/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.
| Catalog Number | R066723 |
| CAS Number | 120533-76-8 |
| Synonyms | 1,4-dihydro-4-phenyl-1-(phenylmethyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester |
| Molecular Formula | C24H25NO4 |
| Purity | ≥95% |
| Target | Epigenetics |
| Storage | -20°C |
| IUPAC Name | diethyl 1-benzyl-4-phenyl-4H-pyridine-3,5-dicarboxylate |
| InChI | InChI=1S/C24H25NO4/c1-3-28-23(26)20-16-25(15-18-11-7-5-8-12-18)17-21(24(27)29-4-2)22(20)19-13-9-6-10-14-19/h5-14,16-17,22H,3-4,15H2,1-2H3 |
| InChIKey | JOHFECBOWRGWJZ-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=CN(C=C(C1C2=CC=CC=C2)C(=O)OCC)CC3=CC=CC=C3 |
| Reference | 1.Mai, A.,Valente, S.,Meade, S., et al. Study of 1,4-dihydropyridine structural scaffold: Discovery of novel sirtuin activators and inhibitors. J. Med. Chem. 52(17), 5496-5504 (2009). |
