For research use only. Not for therapeutic Use.
BML210（Cat No.:I003960）is a selective inhibitor of the protein kinase CK2, an enzyme involved in regulating various cellular processes, including cell growth, proliferation, and apoptosis. By inhibiting CK2, BML210 disrupts signaling pathways often upregulated in cancer, making it a promising candidate for cancer research. Preclinical studies have shown that BML210 can induce apoptosis and inhibit tumor growth in various cancer models. Additionally, it has potential applications in studying CK2’s role in other diseases, such as neurodegenerative disorders. Ongoing research aims to further evaluate its efficacy and therapeutic applications in oncology.
| Catalog Number | I003960 |
| CAS Number | 537034-17-6 |
| Synonyms | BML-210;N-phenyl-N/’-(2-Aminophenyl)hexamethylenediamide |
| Molecular Formula | C₂₀H₂₅N₃O₂ |
| Purity | ≥95% |
| Target | HDAC4 |
| Solubility | DMSO: ≥ 30 mg/mL |
| Storage | -20°C |
| IC50 | 5 μM [1] |
| IUPAC Name | N'-(2-aminophenyl)-N-phenyloctanediamide |
| InChI | InChI=1S/C20H25N3O2/c21-17-12-8-9-13-18(17)23-20(25)15-7-2-1-6-14-19(24)22-16-10-4-3-5-11-16/h3-5,8-13H,1-2,6-7,14-15,21H2,(H,22,24)(H,23,25) |
| InChIKey | RFLHBLWLFUFFDZ-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NC2=CC=CC=C2N |
| Reference | </br>1:The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming. Borutinskaitė V, Navakauskienė R.Int J Mol Sci. 2015 Aug 6;16(8):18252-69. doi: 10.3390/ijms160818252. PMID: 26287160 Free PMC Article</br>2:Histone deacetylase inhibitor BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. Borutinskaite VV, Magnusson KE, Navakauskiene R.Mol Biol Rep. 2012 Dec;39(12):10179-86. doi: 10.1007/s11033-012-1892-5. Epub 2012 Sep 26. PMID: 23007576 </br>3:Retinoic acid and histone deacetylase inhibitor BML-210 inhibit proliferation of human cervical cancer HeLa cells. Borutinskaite VV, Navakauskiene R, Magnusson KE.Ann N Y Acad Sci. 2006 Dec;1091:346-55. PMID: 17341627 </br>4:The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines. Savickiene J, Borutinskaite VV, Treigyte G, Magnusson KE, Navakauskiene R.Eur J Pharmacol. 2006 Nov 7;549(1-3):9-18. Epub 2006 Aug 15. PMID: 16978604 |
