For research use only. Not for therapeutic Use.
BMPO is a cyclic nitrone spin trap that can be used for the detection and characterization of thiyl radicals, hydroxyl radicals, and superoxide anions <em>in vitro</em> or <em>in vivo</em>. The BMPO-<wbr></wbr>superoxide adduct does not rapidly decompose to the hydroxyl adduct in cells (t<sub>½</sub> = 23 min). Also, the ESR spectrum of the BMPO-<wbr></wbr>glutathionyl adduct does not fully overlap with the spectrum of its hydroxyl adduct. Purified by crystallization and stored as a solid, BMPO has a longer shelf life than liquid spin traps.
| Catalog Number | R064940 |
| CAS Number | 387334-31-8 |
| Synonyms | BocMPO |
| Molecular Formula | C10H17NO3 |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C10H17NO3/c1-9(2,3)14-8(12)10(4)6-5-7-11(10)13/h7H,5-6H2,1-4H3 |
| InChIKey | MDMUYJRRYYXDLZ-UHFFFAOYSA-N |
| SMILES | [O-][N+]1=CCCC1(C)C(OC(C)(C)C)=O |
| Reference | 1.Zhao, H.,Joseph, J.,Zhang, H., et al. Synthesis and biochemical applications of a solid cyclic nitrone spin trap: A relatively superior trap for detecting superoxide anions and glutathiyl radicals. Free Radical Biology & Medicine 31(5), 599-606 (2001). |
