BMS-1001 hydrochloride

• CAT Number: I017423
• CAS Number: 2113650-04-5
• Molecular Formula: C₃₅H₃₅ClN₂O₇
• Molecular Weight: 631.11
• Purity: ≥95%

BMS-1001 hydrochloride (CAT: I017423) emerges as a noteworthy orally active inhibitor targeting the PD-L1/PD-1 immune checkpoint pathway. This compound plays a pivotal role in modulating immune responses by inhibiting the interaction between programmed cell death-ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1), key regulators of immune checkpoint signaling. BMS-1001 hydrochloride’s ability to block this interaction suggests its potential in immunotherapy, offering a novel approach to enhance the immune system’s ability to recognize and combat cancer cells.

Reference

[1]. Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181.