BMS-1001

• CAT Number: I023501
• CAS Number: 2113650-03-4
• Molecular Formula: C35H34N2O7
• Molecular Weight: 594.65
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CC1=CC(=C(C=C1OCC2=C(C(=CC=C2)C3=CC4=C(C=C3)OCCO4)C)OCC5=CC(=CC=C5)C#N)CNC(CO)C(=O)O

BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.

Reference

[1] Lukasz Skalniak, et al. Oncotarget. 2017 Aug 7;8(42):72167-72181.