BMS-1166

• CAT Number: I019772
• CAS Number: 1818314-88-3
• Molecular Formula: C₃₆H₃₃ClN₂O₇
• Molecular Weight: 641.11
• Purity: ≥95%
• Target: PD-1/PD-L1
• Storage: Store at -20°C
• IUPAC Name: (2R,4R)-1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid
• InChI: InChI=1S/C36H33ClN2O7/c1-22-26(6-3-7-29(22)25-8-9-32-35(14-25)44-11-10-43-32)21-46-34-16-33(45-20-24-5-2-4-23(12-24)17-38)27(13-30(34)37)18-39-19-28(40)15-31(39)36(41)42/h2-9,12-14,16,28,31,40H,10-11,15,18-21H2,1H3,(H,41,42)/t28-,31-/m1/s1
• InChIKey: QBXVXKRWOVBUDB-GRKNLSHJSA-N
• SMILES: CC1=C(C=CC=C1C2=CC3=C(C=C2)OCCO3)COC4=C(C=C(C(=C4)OCC5=CC(=CC=C5)C#N)CN6CC(CC6C(=O)O)O)Cl

BMS-1166 (Cat No.:I019772) is a potent and selective small molecule inhibitor of the p38 MAPK signaling pathway, specifically targeting the p38α and p38β isoforms. This compound has demonstrated efficacy in modulating inflammatory responses and is being investigated for its potential to treat diseases linked to chronic inflammation, including autoimmune disorders and cancer. BMS-1166 works by inhibiting the phosphorylation of key proteins involved in the p38 MAPK pathway, thereby reducing inflammatory cytokine production and improving disease outcomes..