For research use only. Not for therapeutic Use.
BMS 182874 hydrochloride (Cat.No:I004399) is a potent, selective, and competitive non-peptide endothelin ETAR antagonist. It displays > 1000-fold selectivity over ETB receptors. BMS 182874 hydrochloride inhibits ET-1-induced pressor response in vivo. It inhibits ET-1-i
| Catalog Number | I004399 |
| CAS Number | 1215703-04-0 |
| Synonyms | BMS 182874; BMS-182874; BMS182874; BMS 182874 HCl; BMS 182874 hydrochloride;5-(dimethylamino)-N-(3,4-dimethylisoxazol-5-yl)naphthalene-1-sulfonamide hydrochloride |
| Molecular Formula | C17H20ClN3O3S |
| Purity | ≥95% |
| Target | ETA Receptors |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at RT |
| IUPAC Name | 5-(dimethylamino)-N-(3,4-dimethyl-1,2-oxazol-5-yl)naphthalene-1-sulfonamide;hydrochloride |
| InChI | InChI=1S/C17H19N3O3S.ClH/c1-11-12(2)18-23-17(11)19-24(21,22)16-10-6-7-13-14(16)8-5-9-15(13)20(3)4;/h5-10,19H,1-4H3;1H |
| InChIKey | UZZFRNZGYDOBAO-UHFFFAOYSA-N |
| SMILES | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC3=C2C=CC=C3N(C)C.Cl |
| Reference | </br>1: Katyal T, Garg A, Budhiraja RD. Combination of daidzein, hemin and bms182874 halts the progression of diabetes-induced experimental nephropathy. Endocr Metab Immune Disord Drug Targets. 2013 Jun;13(2):152-62. PubMed PMID: 23701217.</br>2: Bhalla |
