For research use only. Not for therapeutic Use.
BMS-191011 (Cat No.: I003213) is a compound known for its action as a large conductance Ca2+-activated potassium channel (maxi-K channel) activator. This property makes it valuable in the context of stroke research and therapy, as it can help regulate ion channel activity in neural tissue. It has shown effectiveness in stroke models. Researchers studying stroke or related neurological conditions may find BMS-191011 to be a valuable tool. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.
| Catalog Number | I003213 |
| CAS Number | 202821-81-6 |
| Synonyms | BMS-191011; BMS 191011; BMS191011; UNII-LW7MXS978N; Bms-a.;1,3,4-Oxadiazol-2(3H)-one, 3-((5-chloro-2-hydroxyphenyl)methyl)-5-(4-(trifluoromethyl)phenyl)- |
| Molecular Formula | C16H10ClF3N2O3 |
| Purity | ≥95% |
| Target | Potassium Channel |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at RT |
| IUPAC Name | 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-one |
| InChI | InChI=1S/C16H10ClF3N2O3/c17-12-5-6-13(23)10(7-12)8-22-15(24)25-14(21-22)9-1-3-11(4-2-9)16(18,19)20/h1-7,23H,8H2 |
| InChIKey | QKOWACXSXTXRKA-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C2=NN(C(=O)O2)CC3=C(C=CC(=C3)Cl)O)C(F)(F)F |
| Reference | </br>1:BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo. Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K.Biol Pharm Bull. 2011;34(1):150-2. PMID: 21212534 Free Article</br>2:3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR. Romine JL, Martin SW, Meanwell NA, Gribkoff VK, Boissard CG, Dworetzky SI, Natale J, Moon S, Ortiz A, Yeleswaram S, Pajor L, Gao Q, Starrett JE Jr.J Med Chem. 2007 Feb 8;50(3):528-42. PMID: 17266205 </br>3:Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection. Hewawasam P, Ding M, Chen N, King D, Knipe J, Pajor L, Ortiz A, Gribkoff VK, Starrett J.Bioorg Med Chem Lett. 2003 May 19;13(10):1695-8. PMID: 12729644 |
