BMS-195270

• CAT Number: I004421
• CAS Number: 202822-23-9
• Molecular Formula: C15H9ClF3N3O2
• Molecular Weight: 355.70
• Purity: ≥95%
• Synonyms: 2-(5-chloro-2-hydroxyphenyl)-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-one
• InChI: InChI=1S/C15H9ClF3N3O2/c16-8-5-6-12(23)11(7-8)22-14(24)20-13(21-22)9-3-1-2-4-10(9)15(17,18)19/h1-7,23H,(H,20,21,24)
• InChIKey: PHWHYZMFGGOJEU-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C2=NN(C(=O)N2)C3=C(C=CC(=C3)Cl)O)C(F)(F)F

BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux[1].
BMS-195270 (3 μM) produces a dramatic reduction in developed pressure at infusion volumes of 0.2-1.3 mL and inhibits spontaneous contractions in an ex vivo rat whole bladder model[1].
BMS-195270 (2.8 mM) results adult worms of C. elegans displaying an Egl-d phenotype, as well as slowed or arrested pharyngeal pumping (Eat), and uncoordinated motion (Unc)[1].
BMS-195270 inhibits the response of HEK293 cells to the muscarinic agonist Carbachol (HY-B1208) with an EC50 of 2 μM[1].
BMS-195270 inhibits calcium flux, and retains inhibitory activity even when endogenous calcium channels are inactivated[1].

Reference

[1]. Fitzgerald K, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr;2(4):e57.
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